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KMID : 1150720180070040366
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Integrative Medicine Research
2018 Volume.7 No. 4 p.366 ~ p.373
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Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
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Sharma Himanshu
Chauhan Prerna
Singh Surender
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Abstract
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Background: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis.
Objective: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models.
Methods: In formaldehyde model, sub-plantar administration of 0.1?ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3?mg/kg, p.o.) and three groups, treated with 50, 100 and 200?mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-α and IL-1β were measured. Histopathological and immunohistochemical analyses were also performed.
Results: CCHE treatment significantly (p?
Conclusion: Based on these findings, it can be concluded that C. cassia possesses anti-arthritic properties.
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KEYWORD
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Arthritis, Cinnamomum cassia, Complete Freund's adjuvant, Indomethacin, Formaldehyde
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